Research Areas

The INTEG-RNA project focused on the following research areas:​

1) Epigenetic mechanisms in the regulation of gene expression, chromatin assembly, genome stability and telomere homeostasis

• Structure, evolution and maintenance of telomeres and their roles in chromosome stability, DNA repair and plant speciation. Telomerase complex composition and function
• The role of RNA in DNA Repair

2) RNA processing and RNA modifications

• RNA editing/modifying enzymes and innate immuity.
• Crosstalk with RNA modification
• The mechanisms and functions of internal and terminal RNA modifications mostly in mammalian systems

3) Building Machine Learning models for identification of functional binding rules (miRNA:mRNA and RBPs)

• Analysis of RNA-binding proteins in the context of viral infections
• Sequence-specific recognition of single-stranded RNA by RNA-binding proteins
• Systematic measurements of mutational effects in RNA and proteins

4) Single-cell RNAseq and miRNA+mRNAs seq

• The role of noncoding RNAs
• Mechanistic effects of coding sequence mutations in gene regulation
• Bioinformatics of GENE sequencing and quantitative proteomics data